Volume 12 | Issue 11 |

 Abstract

Abstract: This study evaluates the effect of fenugreek seeds on Premenstrual syndrome in teenage girls living in a chosen community in south India.Fenugreek seeds soaked overnight in water was administered to adolescent girls with premenstrual syndrome for 13 days. The severity of premenstrual syndrome was determined using a prevalidated shortened premenstrual assessment form before and after administration of the intervention. The study findings showed a significant reduction in the level of premenstrual symptoms after the intervention among the adolescent girls at p < 0.001 (Z score -5.452).

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 Keywords

Level Of Premenstrual Syndrome, Adolescent Girls, Fenugreek Seeds

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Our ancestors were always functionally fit because they spent their days staying active: walking and running many miles per day; gathering and preparing food; hunting/fishing; playing sports and holding athletic competitions; taking care of children; building homes; the list goes on. In indigenous cultures, for most of history, movement was so heavily integrated into daily life that the ancestors did not need a gym or special space for "fitness," and there was no need to set aside extra time for fitness training. Today, the world is different. People are often stuck behind a desk or sitting on a couch or in a car most of the day. Because of our sedentary lifestyles, we need to focus on spending some extra time training in order to avoid becoming sick with modern lifestyle diseases such as diabetes or obesity. Hence Fitness, today as we all know has become a buzz word. Coaches, athletes, personal trainers, athletic trainers, physical therapists and even the general public have woken up big time to fitness. But do these people choose a proper and effective fitness regime? Today we have many fitness concepts catering to different priorities but what we will be discussing today is the backbone of all fitness training. Every human being irrespective of his occupation involves himself in some or the other physical movement and every movement has a purpose. To make the movements efficient a training method has to be purposeful. Our bodies are an amazingly complex web of interconnected muscles, joints, fascia, ligaments, tendons, bones, and other tissues and organs that work synchronously and seamlessly. When we are lean and fit, every cubic centimeter of our bodies has a purpose, a function to help us survive and thrive. We all know that our body is this interconnected web that's really more like one unit, one muscle, Then why would we focus on only one muscle group during a workout or one type of exercise activity? The idea of focusing on only one muscle group in a workout is definitely not efficient, nor is it athletic.

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 Keywords

Functional Fitness, WELLNESS, SPORTS

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 Abstract

The transdermal drug delivery system (TDDS) has established itself as an essential component of new drug delivery systems. The term "transdermal delivery system" refers to all topically given medication formulations that transport active ingredients into the body's circulation. Transdermal drug delivery systems are polymeric formulations that, when applied to the skin, deliver the drug at a predetermined mined rate throughout the dermis to produce systemic effects. Although transdermal dosing options are more expensive than traditional formulations, are gaining popularity due to their distinct advantages. Controlled absorption, more consistent plasma levels, increased bioavailability, minimized adverse effects, painless and uncomplicated application, and the option of discontinuing drug administration by simply removing the patch from skin is one of the potential benefits of transdermal medication administration. Development of controlled release transdermal dosage form is a complex process involving extensive efforts. This review article describes the methods of preparation of different types of transdermal patches, evaluation parameters and some available marketed products.

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 Keywords

Transdermal Drug Delivery System, Patches, Convenient, Skin, Evaluation of TDDS.

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Nanobubble technology, characterized by gas-filled bubbles smaller than 1?m, presents a novel approach for enhancing drug delivery in cancer therapy. These nanobubbles facilitate targeted therapy by improving the biodistribution and bioavailability of therapeutic agents at tumor sites, leveraging their ability to extravasate through leaky vasculature. The structural composition of nanobubbles, primarily consisting of various gases encapsulated by a shell made from proteins, lipids, and polymers, plays a crucial role in their stability and efficacy. This review explores the unique physicochemical properties of nanobubbles, various methods for their production and characterization, and their applications in targeted drug delivery, gene therapy, and theragnostic, and overcoming challenges such as drug resistance and toxicity. The promising results from in vitro and in vivo studies highlight the potential of nanobubbles as a versatile tool in cancer treatment, underscoring the need for further clinical trials to validate their safety and effectiveness.

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Nanobubble technology, Drug delivery, Cancer treatment, Targeted therapy, Ultrasound, Cell membrane permeability, Enhanced permeability and retention (EPR)effect

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Creative Commons Attribution 4.0 and The Open Definition

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Indian is known for traditional medicine.Herbs are the traditional form of Indin medicine which was developed by acient sages whose astute observations led to the development of constitutional medicine.Herbal cosmetics are the prepartions used to enhance the human apperance. Dandruff is a skin condition with symptoms includes flaking and sometimes mild itchiness cause to scalp. There are many bacteria ,fungus causing scalp infections which lead to further hair problems or skin issues. There is one of the common condition CANDIDIASIS which i typically caused on skin or mucus membrane caused by candida. Flaxseed(Linumu sitatissimum) is annual plant of the linaceae family with several biological properties such as an indirect effect on hair regrowth through the intermediary. Flax seed gel has several benefits on 4C hair. The gel is rich in omega-3-fatty acids,vitamins,minerals and lignin.

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Keywords:-Herbal hair gel, flaxseed, chia seed, vitamin E, & antioxidants.

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The primary accent of this work is to design and optimize digital circuits, with particular focus on multiplexer topology, which includes reversible multiplexer and demultiplexer modules harboring ideas other than the conventional CMOS transistors. Allowing for logic gates and linkages at the nanoscale were unique processes by which the suggested circuits could store binary information. Since reversible multiplexers and demultiplexers, by design, do not let go of information, thus allowing for the minimized power dissipation associated with their working, they are suited for low-power applications. These new ways of doing things have a bunch of advantages, prominently among them is the low power, fast speed, which makes them future candidates for low-power, high-performance applications of nanoscale electronics.

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Reversible Multiplexer, Information Loss Prevention, Low-power Application, Power Dissipation Reduction, Power Efficiency and Delay Optimization.

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Due to such wide significance, this drug delivery system may lead to better patient compliance and ultimate clinical output. For the treatment of inflammatory bowel colon targeting microsponges drug delivery system has been applied on the affected areas because the conventional drug therapy used to treat IBD mainly includes the use of anti-inflammatory drugs which encounters obstacle such as absorption and degradation in the upper GIT and also causes serious side effects in upper GIT. Microsponge delivery system (MDS) is the unique technique which provides targeted and controlled release of drug. Another added advantage of microsponges which contributes to their use is the ability of retaining drug on the surface of colon ensuring local and targeted action. Consequently, the lag time for drug absorption increases which makes MDS suitable for colon specific delivery and microsponge produce specific drug targeting with reduced side effects of drug.

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Colon Targeted, Microsponge, Mesalamine, Inflammatory bowel disease, Synthetic polymer

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Louise Erdrich's novel LaRose explores the complex interplay between Catholicism and Ojibwe spirituality within the context of cultural and religious conflict. The narrative from centres on the tragic accidental killing of a young boy, Dusty, by the Ojibwe Irons family and the subsequent adoption of their son, LaRose, by the grieving Ravich family. This episode, rooted in Ojibwe tradition, fosters healing and reconciliation between the two families. Erdrich delves into the spiritual significance of naming, adoption, and ritual in Ojibwe culture, highlighting how these practices help individuals and communities navigate trauma and traumatic experience. The novel contrasts Ojibwe's holistic approaches to healing with Catholic and Western methods, emphasizing the importance of maintaining cultural traditions in contemporary life.

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Ojibwe spirituality, Catholicism, cultural conflict, adoption, naming, rituals, healing, reconciliation.

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Creative Commons Attribution 4.0 and The Open Definition

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D-Mart, a leading retail chain in India, has achieved significant success through its focus on low prices, wide product selection, and customer convenience. However, the company faces challenges such as increasing competition, rising costs, and shifting consumer preferences. To maintain its market position, D-Mart must continue to innovate, improve operational efficiency, and adapt to changing market dynamics.

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D-Mart, retail, discount retailer, low prices, customer experience, supply chain management, competition, sustainability, digital transformation.

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The extensive coal mining activities in Chandrapur, Maharashtra, have led to significant environmental degradation and pose serious health risks to coal miners. This study assessed the health impacts of long-term coal dust exposure, with a specific focus on the fungal species present in the Pauni-II Expansion Opencast Coal Mine environment and their potential effects on workers. Using air and skin samples, fungal species were isolated and identified from miners and the surrounding environment. Petri plates containing Sabouraud Dextrose Agar (SDA) and Potato Dextrose Agar (PDA) were used to collect airborne fungi at various distances (0m, 100m, 300m, 500m) from the mine entrance, while skin samples were collected from miners exposed to coal dust. A total of 12 fungal genera were identified, with Aspergillus (19.2%), Candida (19.2%) and Trichophyton (17.5%) being the most prevalent in air samples. Skin samples revealed a predominance of Candida species (86.7%), indicating potential risks for skin infections among miners. Respiratory health data collected through an online survey of 80 miners highlighted the prevalence of symptoms such as persistent coughing (60%), asthma exacerbation (38.75%) and reduced lung function (43.75%). The findings underscore the urgent need for improved ventilation, protective equipment and regular health monitoring to mitigate the occupational health risks in coal mining. These results contribute valuable insights into the fungal hazards in mining environments and provide evidence-based recommendations for enhancing worker safety protocols.

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 Keywords

Coal Mines, Mining Industry, Fungal Impact, Respiratory Issues, Preventive Measures, Environmental Health, Occupational Health

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