Volume 12 | Issue 12 |

 Abstract

Diabetes Mellitus (DM) is a chronic metabolic disorder characterized by elevated blood glucose levels (hyperglycemia) either from inadequate insulin synthesis or impaired insulin sensitivity. Diabetes mellitus ranks among the top ten major causes of mortality in the 21st century. By 2045, the International Diabetes Federation (IDF) estimates that almost 783 million persons, or 1 in 8, would have diabetes, representing a 46% rise. Hematological markers, including total white blood cell (WBC) counts, lymphocytes, and neutrophils, have been associated with the onset of type-2 diabetes. Increased white blood cell counts correlate with insulin resistance and pancreatic beta-cell impairment. Lagerstroemia speciosa, a tropical and subtropical species indigenous to Asia, is a viable contender for the Western Ghats, a biodiversity hotspot in India, especially around Coimbatore. The experimental animals were divided into six groups with n=6 animals. The groups III, IV, V, and VI are the experimental groups, orally fed with LELE Low Dose and High Dose (250 and 500 mg/kg body weight), and the II the standard groups treated with glibenclamide. The after 21st day evaluated for the estimation of biochemical parameters and haematological parameters. A histopathological evaluation was also performed. The results show that the treated groups showed a significant (***P<0.001, **P<0.01, *P<0.05) elevation compared to the control group. Effective diabetes management frequently necessitates regular complete blood counts, illustrating the need of early identification and management of anemia and obesity in diabetic patients in primary care environments. Plants provide an appropriate substitute to manufactured pharmaceuticals, acting as possible sources of hypoglycemic drugs. Conventional medicinal systems extensively utilize these botanicals for diabetes prevention. Herbs, such as the decorative and medicinal herb L. speciosa, have demonstrated potential antidiabetic properties. Furthermore, anthocyanins, which are polyphenolic substances present in food, may significantly contribute to the prevention of type-2 diabetes.

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Anthocyanin, Lagerstroemia speciosa, Herbs, Glibenclamide, Diabetes Mellitus, hypoglycaemic, Pancreatic beta cells.

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Antipsychotic medications are first-line medication treatment for schizophrenia and while theycan be effective in managing symptoms, they can also have significant adverse effects. However, caregivers may not always have adequate knowledge about the adverse effects of antipsychotic drugs, which can lead to poor treatment outcomes. The side effects of antipsychotics not only damage the health of patients, but also increase the burden and stress of caregivers. However, caregivers have different attitudes and coping styles about the side effects of antipsychotics. The aim of the study was to assess the effectiveness of Self Instructional Module on knowledge regarding adverse effects of antipsychotic drugs among care givers of Schizophrenic patients in selected tertiary care hospital of the city. Methods : One group pre test post test method was undertaken where 100 caregivers of Schizophrenic patients were recruited as sample by non-probability convenient sampling method. Using structured questionnaire for knowledge (25 questions) data were collected. Data analyzed using both descriptive and inferential statistics to describe and show the association between knowledge and the variables Result : The study result depicted that Among all caregivers 24% of the caregivers had poor knowledge (score0-8), 58% of them had average knowledge (score 9-16) and only 18%of caregivers had good knowledge (score 17-25) in pre-test whereas in post-test 1% of the caregivers had poor knowledge, 30% of them had average knowledge and 69% of them had good knowledge. The comparisons of the pre- test and post- test mean score of the knowledge were done by the paired t test. Average knowledge score in pre-test was 12.52 which increased to 18.91 in post-test. 't' value for this test was 11.9 with 99 degrees of freedom. Corresponding p-value was small (less than 0.05), the null hypothesis is rejected. Knowledge score in post-test was significantly high as compared to that in pre-test Conclusion : Present study concluded that the Self Instructional Module have significant improvement in knowledge about adverse effects of antipsychotic drugs among caregivers of Schizophrenic patients, it has enriched features such as self explanatory, self understanding, self directed, self motivated and self evaluating ,a finding reveals that Self Instructional Module was effective in improving knowledge and awareness regarding adverse effects of antipsychotic drugs and its management

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Knowledge, antipsychotic drugs, adverse effects, Self Instructional Module

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Alcohol dependence is a most alarming issue in the world nowadays. It is a psychiatric diagnosis in which a person continues to use alcohol despite negative consequences to relationship, work, or quality of health and life. Madya has nectar like properties when used judicially following all norms, otherwise it acts as poison. Madya possess all the qualities of Visa and indiscriminate use of Madya causes Madatyaya. As per ayurvedic concept Madatyaya is Tridoshaja vyadhi mainly Kapha sthana is vitiated along with Agni. Nidana is the primary cause of manifestation for every Vyadhi and Nidana Parivarjana is thought to be a sort of cure. Nidana Parivarjana and there by practising Pathya, one might reduce the likelihood of experiencing Vyadhi by being aware of the Nidana. Though, finally it will give a proper knowledge regarding the etiological factors of Madatyaya in the present era.

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Madatyaya, Nidana, Alcohol, Alcohol dependence, Alcohol intoxication.

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In this study the author reviewed the teacher training programmes of India from Vedic period to modern period. The key features given about NEP2020 regarding teacher training programme. Discussed about four-year Integrated Teacher Training Programme framework given by NCTE. ITEP will be available for all students who choose teaching as a profession after Secondary, by choice. This integrated course will benefit students since they will save one year by finishing the course in four years rather than the customary five years required by the present B. Ed. The ITEP provides hands-on experience through classroom activities, field placements and internships.

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Teacher Training Programme, ITEP, Stage Specific Specialisation, Multiple Entry and Exit, and Re-entry Options, Nomenclature of Degree

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The siddha system is one of the oldest systems in India. The basic principles of siddha system include three vital humors (Vatham, Pitham, Kabam). Any imbalance of three humors leads to disease. According to siddha science to prevent the ageing process, they discovered and used various kinds of treatments like Muppu, Kaya kalpam, Yoga and also internal medicines. Neerdaipu ennai is a liquid form of internal medicine indicated for Neeradaipu in siddha literature. The investigation aimed to assess the biochemical analysis of the trial medicine Neeradaipu ennai, demonstrates the presence of sodium, iron and alkaloids. As a result, I conclude that the existence of these substances will be effective in the treatment of Prosthakola vekkam.

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Prosthakola veekkam, Neeradaipu ennai, Benign prostatic hyperplasia, Biochemical analysis.

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The Real Estate (Regulation and Development) Act, 2016 (RERA) is a historic piece of legislation designed to improve consumer protection, accountability, and transparency in the real estate industry in India. This research thoroughly assesses the effects of RERA on the real estate sector since its implementation, emphasizing the effectiveness of the law in resolving persistent problems such project delays, financial irregularities, and disputes between developers and buyers. The act's requirements for escrow account use, required project registration, and severe penalties for non-compliance--all of which work to protect the interests of consumers and encourage on-time project delivery--are among the important features that are examined. The study also emphasizes important implementation obstacles that stakeholders must overcome, such as states' delayed adoption, differing interpretations of RERA rules, and early compliance barriers. These difficulties have affected the speed and consistency of RERA's implementation around the nation, which has affected the law's overall efficacy. The report provides insights into the changing dynamics of the real estate market post-RERA, including shifts in investor sentiment and consumer confidence, by utilizing empirical data, case studies, and stakeholder viewpoints. The report culminates in suggestions for fortifying the RERA's regulatory structure, refining procedures for resolving disputes, and raising stakeholder consciousness in order to maintain and optimize its favorable effects on the Indian real estate sector.

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Transparency, Accountability, Implementation, Compliance, Regulatory Framework.

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21st century is the boon era of development in Technologies and Science, at the same time people are becoming the victim of lifestyle disorders. One such type of disorder is Hyperlipidemia. Abnormal high concentration of lipids in blood caused by abnormal lipid and lipoprotein metabolism is expressed as Hyperlipidemia. Though there is no precise terminology for Hyperlipidemia mentioned in Ayurveda classics, various scholars have tried to use distinct nomenclature for the same. The description of Shonithaabhishyanda matches with clinical state of Hyperlipidemia. It is a condition mentioned by Acharya Charaka, where Santharpanajanya Nidana and Viruddha ahara are the contributary factors. As a result, a particular questionnaire based on Viruddha ahara and Santarpanotha nidana was developed in order to look into etiology and pathogenesis. Understanding etiology and pathogenesis is the age old tool for diagnosis and management of any disease. By knowing the exact etiopathogenesis of Shonithaabhishyanda , one can prevent from the further sequels like Dhamani Prathichaya, Margavarana and related catastrophic events.

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Shonithaabhishyanda, Viruddha ahara, Santharpanajanyanidana,Hyperlipidemia

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Many proposed microfluidic biosensor designs are based on the measurement of the resonances of an optical microcavity. Fluorescencebased resonators tend to be simpler and more robust than setups that use evanescent coupling from tuneable laser to probe the cavity. In all sensor designs the detection limits depend on the wavelength resolution of the detection system, which is a limitation of fluorescence-based devices. In this work, we explore the ultimate resolution and detection limits of refractometric microcavity sensor structures. Because many periodic modes are collected simultaneously from fluorescent resonators, standard Fourier methods can be best suited for rapid and precise analysis of the resonance shifts. Simple numerical expressions to calculate the ultimate sensor resolution and detection limits were found, and the results compared to experiments in which the resonances of fluorescent-core microcapillaries responded to various sucrose concentrations in water.

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Refractometric Microcavity, Fluorescent-core Microcapillaries

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Introduction: COVID-19 is a highly contagious disease that emerged in 2019 in Wuhan, China and caused a huge death toll all over the world. Objective: This study aims to analyze the impact of Covid-19 on Online Food Delivery Applications. Target Audience and Methods: This study was based on a sample of 583 people above 18 years of age and of all genders. Classification was based on different factors like eating preferences, food delivery app used, etc. Statistical analysis was performed using Microsoft Excel, SPSS and Jupyter. Conclusion: Consumer experience was found to have a significant impact by COVID-19 through statistical analysis helping the Mobile food delivery apps establish a long term relationship with the customers.

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Covid-19 Pandemic Corona Virus Food Delivery Apps Statistical Analysis Digital Platforms

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