Volume 12 | Issue 2 |

 Abstract

Energy drink (EDs) with caffeine is widely ingested. Over the past 20 years, use of energy drink has drastically increased, especially among adolescents and young people. Energy drink are aggressively advertised with the promise that they would offer you more energy and raise your mental and physical performance. With the help of clever and successful marketing techniques, the general public and athletes have increased their consumption of energy drinks (EDs). There are a growing number of reports of caffeine intoxication from caffeinated EDs as well as issues with dependence and withdrawal from caffeine. The neighborhood and the general populace. Energy drink usage poses health risks mostly because of their high caffeine content. However, a number of unfavorable health effects have been linked to energy drinks, raising the question of their safety. This review was done to find and talk about the published publications that looked at the negative health impacts of caffeine and energy drink consumption. The goal is to evaluate consumption habits and identify any negative effects. The consequences of EDs and their possible harm are examined in greater detail in this article.

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 Keywords

Energy drinks, Beverages, Health effects, Consumption

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Haryana, a northern state of India has earned quite a reputation for its rapid economic growth and technological advancements over the years. Paradoxically though the economic progress has not translated into social development. The social scene of the state paints a rather dismal picture with longstanding female deficits and gender discrimination which has created an imbalance in the proportion of marriageable males and females in their respective cohorts. The consistently skewed sex ratios of the state have inadvertently led to the presence of relatively less females in comparison to males on the matrimonial landscape, thus, ensuing the crisis of male marriage squeeze which has pushed a substantial number of its socio-economically disadvantaged men to the cusp of involuntary bachelorhood. This shortage of brides is being addressed through non-customary cross-region marriages whereby men are marrying (or purchasing) women as wives from impoverished regions of eastern and southern India. In these matrimonial alliances that are driven by necessity, compulsion and convenience, is manifested inhuman treatment of the incoming brides. For a number of these pardesi bahu's discrimination, subjugation and violence has become a harrowing reality. There are instances where they have been victims of trafficking, forced marriages and domestic violence. Some distressing incidents of these cross-region women having been sold by their parents/relatives and purchased by their alleged partners like a commodity have also been noted. They are often refused respectable status and denominated as servants in host societies. This paper, situated in the rural backdrop of Haryana draws heavily from field research carried out in its six villages to lay bare the perturbing physical, emotional, sexual abuses and inhuman treatment meted out to cross-region brides in their alien conjugal settings.

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Male Marriage squeeze, cross-region brides, domestic violence, trafficking, forced polyandry.

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It is a prospective ethically designed investigation in human subjects to objectively discovered /verify/compare the result of two or more therapeutic measures (Drugs).clinical trials are designed to answer one or more precisely framed questions about the value of treating equivalent group of patient by two or more modalities (drug , dosages, regiment and other investigation ).depending on other objectives of studies , clinical trial may be conducted in healthy volunteers or in volunteer patient.Healthy volunteers may be used to determine pharmacokinetics characteristics,tolerability,safety for the certain type of drug even efficacy. The research carried out to find a better treatment, improve healthcare, and benefit the current medical practice is termed clinical research. In phase I pharmacokinetics, safety, gross effects are studied on human volunteers, by clinical pharmacologists. If the drug passes the test, it enters phase II testings, where pharmacokinetics, safety, therapeutic efficiency are studied on selected patients by clinical pharmacologist, if passes hundreds of selected patients are now studied, primarily for safety and therapeutic effectiveness by clinical investigators in phase III. If this is passed the drug is now approved and marketed. Even after marketing, physicians from various hospitals and clinics send their opinion about the drug, regarding ADR, efficacy in phase IV. In this paper we discuss about clinical trials and clinical trials in India.

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Clinical Research, Clinical Trial, Human Health, Safety and Efficacy, Volunteers study, ICH Guideline, Preclinical Study, In-Vitro study, Adverse effect, Randomization.

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The study sheds light on the "Fourth-order rotatable slope design" to evaluate the overall methodology and statistical process to determine the connection between response variables and independent factors. It has been identified that FORSD with BIBD optimises the statistical poutine and constructive insights by minimising the number of experimental runs. The methodology section evaluates the general consequential steps of analysing relevant data through BIBD including statistical analysis and "response surface analysis". The statistical method of obtaining "group-divisible fourth-order rotatable designs" has been evaluated with mathematical expression. The outcome shows an in- depth understanding of the effect of influencing factors on the specific response variable. This study is extremely significant as "fourth-order slope design" gives better insights into the relationship between DV and IV and can be effectively applied for industrial and research purposes in various sectors.

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 Keywords

"Fourth-order rotational slope design", BIBD, TORD, response variables, influential factors, "fourth-order slope design", and "response surface analysis".

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Creative Commons Attribution 4.0 and The Open Definition

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It became at some point of the British generation that the desire at no cost and compulsory training began. The founders stipulated that the aim of Article 45 should be accomplished within ten years of the charter's adoption. The Eighty Sixth Amendment Act of 2002 (Amendment Act, 2002) mounted schooling as a essential proper following some of court rulings. The Children Right to Free and Compulsory Education Act 2009 (RTE Act, 2009) became passed so one can perform this venture. Nevertheless, the RTE Act's requirement that best training be provided at a minimal stage of gaining knowledge of has not been met through the authorities. Providing exceptional training at a minimal stage is one of the newline parameters of the extraordinary Monitoring Tool beneath the Sarva Shiksha Abhiyan (SSA).

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KEYWORD: Between 6 to 14 years, disadvantaged group, free and compulsory education, law, social sciences, weaker section.

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Agile methodologies have gained popularity in financial software development for their emphasis on adaptability, cooperation, and continuous improvement. This paper explores how adopting Agile benefits banking by comparing it with traditional waterfall approaches and investigates its impact on digital banking transformation, including the key elements of people, procedures, technology, and culture. It examines the adoption of agile methodology in digital banking projects lead to improved project delivery timelines, software quality, and customer satisfaction. Also investigating the challenges and benefits associated with implementing these methodologies within a regulated environment. highlighting agility's pivotal role in facilitating digital banking transformation while maintaining competitiveness.

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Agile project management,Digital banking,Software Project Management, Adaptive software development

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This study aims to investigate the stability of resilient microgrids that use flexible AC transmission system (FACTS) devices. Microgrids are a popular way of integrating various distributed energy resource (DER) technologies into the distribution system. However, the use of electronic power converters (EPCs) to couple these DER technologies has created new operation challenges that could affect microgrid stability, reliability, and resilience. Induction motor-type loads (IMs) are dynamic loads that are commonly found in distribution grids and air conditioning (A/C) types of loads. These loads demand a lot of reactive power for correct operations. This high demand could lead to a phenomenon called fault-induced delay voltage recovery (FIDVR), which can cause problems with dynamic voltage stability (DVS). To address these challenges, this study proposes the incorporation of FACTS controllers, such as a static VAR compensator (SVC) and a distribution static compensator (DSTATCOM), into the microgrid as reactive power supply resources. This proposal includes designing, optimal location, and dynamic modeling of FACTS devices to enhance microgrid operation resilience.

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 Keywords

Resilient Microgrids, Dynamic voltage stability, Fault-induced delay voltage recovery (FIDVR), FACTS, SVC, DSTATCOM,

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Abstract Investment pattern of salaried employee are quite different, the character of employment and income level plays an essential role, but one factor is common for all its regular basis of income may result in eventual investment or monthly saving habit rather than payment saving. This research focused only on salaried persons. Investors are unaware of various investment avenues; meanwhile non-investors are unaware of importance and benefits of investments. This study is that specialize in the pattern, preference, purpose, problem and awareness of Investments by salaried class people and it'll be helpful to spot the higher investment options within the market. 52 respondents constituted sample covering NBFC. Percentage analysis, Chi-Square test and rank analysis are used for research purpose. It can be concluded that salaried employees are conscious of various investments and satisfied with their investments.

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Keywords: Investment Avenues, Investment Portfolio, Salaried employees, Awareness.

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Phytochemical investigation was the scientific procedure to extract, examine, analyse and identifying different phytoconstituents present in various plant parts for the discovery of drugs, the active components could be further taken for investigation and research. The present research work is primarily aimed to carry out phytochemical investigation to detect the major classes of bioactive compounds presented in Musa paradisiaca leaves. Many solvents like Methanol, Ethanol, Acetone, Petroleum ether, Chloroform, Ethyl acetate, Cyclohexane and Acetic acid were used to screen the best solvent which can be used for extraction and to perform chromatographic technique of extracts. For thin layer chromatography, silica gel plates were used and mobile phase was Ethanol:Methanol:Chloroform in (1:1:1 ratio) for all extracts. Phytochemical investigation shown the presence of major components like Alkaloids, flavonoids, tannins, phenols, glycosides, saponins and steroids in Musa paradisiaca leaves. Among different solvent extracts, methanol extract shown high. Further thin layer chromatographic studies were done with the Musa paradisiaca leaf extract, observed different coloured bands of phytochemical compounds with different Rf values. In this methanol extract shown seven bands with Rf less than 1 for 24 hrs. Column chromatographic studies with methanolic extract was done to determine better separation, the mobile phase used was Ethanol:Methanol:Chloroform. The research work was concluded that the methanol extract of Musa paradisiaca leaves contain a higher amount bioactive compounds and methanol as a solvent shown effective separation of bioactive compounds, which can be used for future research on this plant.

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 Keywords

Musa paradisiaca, Phytochemical investigation, Thin layer chromatography, Column chromatography

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Creative Commons Attribution 4.0 and The Open Definition

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Abstract: Bacopa monnieri (Family: Scrophulariaceae) also known as Bramhi is an important medicinal food plant in the Indian subcontinent. Bramhi is used for enhancement of memory, intelligence and to treat neurodegenerative disorders. Pharmacological activities of Bacopa monnieri include anti-epileptic, anticancer, anti-ulcer and anti-inflammatory etc. This review attempts to encompass the available literature on Bacopa monnieri with respect to its pharmacognostic characters, cultivation, chemical constituents and summary of its various pharmacological activities and clinical uses.

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 Keywords

Index Terms - Bacopa monnieri , pharmacology, cultivation, phytochemistry.

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