Volume 12 | Issue 3 |

 Abstract

Recent research suggests that asthma genetics is significantly influenced by pathways involved in inflammation, airway remodeling, and epithelial activation. Transcriptome analyses have identified genes that are differently expressed in response to allergens or interleukins, eosinophil apoptosis, the arginase pathway, and inhaled corticosteroids. A1AR and CLCA1 genes (chromosome 1), IL-1RN and DPP10 (2q14), HLA-G and TNF-(6p21), GPR (7p14), FcRI and GSTP1 (11q13), NOS1, IFNG, STAT6, VDR, and other genes (12q13-26), PHF11 and flaking genes (13q14), AACT and PTGDR (14q), and ADAM33 (20p13) are just a few of the genetic regions that have been identified by candidate gene and genome-wide studies. Future research, ideally longitudinal in nature, is required to confirm the involvement of these and other genetic variables.

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 Keywords

association, asthma, atopy, expression, gene, genome, haplotype.

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The COVID-19 pandemic has reshaped the world, underscoring the need for rapid advances in medicine to address its widespread impact. This paper examines various aspects of COVID-19 vaccine development, focusing on new developments, challenges and wider implications in a global context. Examines the challenges of vaccine development, from early research phase to clinical trials and regulatory approval, elucidates various vaccines and their mechanisms of action Effectiveness and safety considerations play a role especially with an emphasis on a rigorous testing program and ongoing research to ensure public confidence. The paper examines the challenges of global vaccination, addressing equity challenges, logistic barriers, and vaccine delays. In addition, the profound social consequences of successful advocacy campaigns are discussed, showing implications for public health, economic stability, and international relations Finally, the importance of there is a need to continue to emphasize research, collaboration and equitable access to vaccines as essential components of global health protection and epidemic prevention .

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COVID-19, VACCINES, PHARMACEUTICAL,EFFICACY

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Acyclovir used in Herpes Simplex Infection (e.g. cold sores, genital herpes), Herpes Zoster Infection (e.g. shingles) and Vericella Infection (e.g. chicken pox), is absorbed mainly from stomach and upper gastrointestinal tract. Food does not affect absorption of acyclovir. The dose of Acyclovir is 200 mg, 400 mg and 800 mg. The gastroretentive in-situ gelling drug delivery system can incorporate high dose (750-1000 mg) of the drug. The tablet for such a high dose will be large in size. Thus, it will not be patient compliant for patients having difficulty in swallowing, pediatrics, and geriatrics. Thus, the liquid dosage form is preferable. Dispersible tablets, conventional coated and uncoated tablets, capsules, suspensions, ointments and parenteral of Acyclovir are available in market. All these dosage forms show the half-life of 2-3 hours. Thus, dosing frequency is more. To reduce the dosing frequency, sustained release dosage form will be helpful.

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Site specific, Gastroretentive, Acyclovir, Floating, In-situ gel

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 Abstract

We try to estimate the costs that an offline password cracker would take if they wish to undertake an attack lasting L days and successfully crack all the passwords under the given password space hashed by algorithm A. This research will involve analysing the various factors that contribute to the overall cost of password cracking, such as computing power, time, and resources. We say that using cost to crack as password strength is better than time to crack a password.

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 Keywords

Password cracking, Prediction, Estimating, Cloud services, Recurrent Neural Networks.

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A teacher-made test is an assessment created by an instructor to evaluate students' understanding of a particular subject or topic. These tests are designed by the teacher based on the learning objectives, curriculum, and materials covered in the classroom. They can include various types of questions such as multiple-choice, short answer, essay, or problem-solving questions tailored to assess the students' knowledge, comprehension, and critical thinking skills. Teacher-made tests are an essential tool for gauging student progress and informing instructional decisions.

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TEACHER-MADE-TEST

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Assessment is the systematic basis for making inferences about the learning and development of students. It is the process of defining, selecting, designing, collecting, analysing, interpreting, and using information to increase students' learning and development. The four pillars of assessment are purpose, validity, reliability and value. Assessment is not an end in itself but a vehicle for educational improvement. There is no perfect tool of assessment with Efficiency and Fairness. All the assessment methods, material models, tools should be introduced in advance before going for the actual assessment. Pay attention to learner wellbeing- Psychological and Consider the potential consequences of assessment. The main challenges in assessment are higher order skills like creativity, innovation, evaluation, critical thinking, computational thinking etc. Automation of assessment so that self-assessment is promoted to validate and use the existing tools in the market. The challenges continuous as effective use of Aggregate and Disaggregate data for assessment decision, data generation, curation of skills, formative assessment individual level and following individual learning styles. The assessment may be text based descriptive responses and creating proper rubrics by integrating market expectations (skills, knowledge) into assessment tools based on the market acceptance for our assessment.

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Assessment, competencies, cognitive domain, Challenges and Validity.

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The concept of disability refers to a physical, sensory, cognitive, or mental impairment that may limit an individual's ability to participate fully in society or perform certain tasks. It's important to recognize that disability is not solely a medical issue but also influenced by social, cultural, and environmental factors. Disability can vary in severity and impact, and it's crucial to promote inclusion, accessibility, and respect for the rights and dignity of people with disabilities. The Rights of Persons with Disabilities Act (RPWD Act) was passed in India in 2016 with the aim of safeguarding and promoting the rights of persons with disabilities. The act replaced the Persons with Disabilities (Equal Opportunities, Protection of Rights and Full Participation) Act of 1995. Key features of the RPWD Act include expanding the scope of disabilities covered, recognizing new categories of disabilities, ensuring accessibility, promoting inclusive education, employment, and social security, and establishing mechanisms for the implementation and enforcement of disability rights. The act seeks to create an inclusive and barrier-free society where persons with disabilities can fully participate and contribute.

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Physical Disabilities, Sensory Disabilities, Cognitive Disabilities, Psychiatric Disabilities,Communication Disabilities, Neurological Disabilities,Chronic Health Conditions.

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The research article delt with the title of 7.5% Government reservation for higher education enrolment for the students of Government schools in Tamil Nadu. The 7.5% scheme is introduced by the Government of Tamil Nadu in the year 2021. The focus of the scheme is to offer the opportunity to the Government school students to enter their Higher Education in the reputed Government and private medical, veterinary, fisheries, engineering, agriculture and Law colleges and Universities. The primary objective of the research is to assess the awareness among the 12th on going students of Government schools in Tamil Nadu. From the finding it reveals that 71% not aware the 7.5% reservation scheme for the enrolment of the Higher Education in the state of Tamil Nadu. It is recommended that the Career information program should be provided to government higher secondary students to know about the various welfare scheme, courses, and its entrance exams availability through qualified career counselor.

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Government scheme, 7.5% reservation, Career awareness and facilitating role of teacher.

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Tinospora Cardifolia (Menispermaceae) is an Ayurvedic medicinal plant distributed throughout the Indian subcontinent and China. The whole plant is used in folk and the Ayurvedic system of medicine alone and in combination with other plants. Due to its commercial importance T. Cardifolia has been of intense research interest for the last four decades with the isolation of diverse compounds such as alkaloids diterpenoids phenolics steroids aliphatic compound and polysaccharides along with discovery of a wide spectrum of Pharmacological properties like immunomodulation anticancer hepatoprotective and hypoglycemic. Although pharmacological activities of extract and compounds of T. Cardifolia have been studied in both vitro and in vivo only a few mechanisms of action have been explored. In the present review the pharmacological activities of compounds and different extracts of T. Cardifolia are highlighted along with those of the marketed products. This compilation of the extensive literature of T. Cardifolia here will be referral point of clinical study and the development of standardized phytomedicine in healthcare.

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Tinospora Cardifolia, review, Pharmacological activity, CHEMICAL CONSTITUENTS.

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The development of Self Compacting Concrete (SCC) is progressive milestone throughout the entire existence of construction industry bringing about prevalent utilization of SCC overall these days. It has numerous benefits over ordinary cement regarding upgrade in efficiency, decrease in labor and generally cost, amazing completed item with magnificent mechanical reaction and solidness. Joining of fibers further improves its properties extraordinarily identified with post break conduct of SCC. Henceforth, the point of the current work is to make a similar investigation of mechanical properties of self-merging concrete, supported with various kinds of fibers. The factors include in the examination are type and diverse level of strands. The fundamental properties of new SCC and other properties were studied. The fibers used in the study are 15 mm long chopped glass fiber, carbon fiber and basalt fiber. First stage comprised of improvement of SCC mix design of M20 grade and in the subsequent stage, various fibers like Glass, basalt and carbon Fibers are added to the SCC blends and their new and solidified properties were resolved and thought about. The investigation showed noteworthy enhancements overall properties of self compacting concrete by adding strands of various sorts and volume parts. Carbon FRSCC displayed best execution followed by basalt FRSCC and glass FRSCC in solidified state while most unfortunate in new state attributable to its high water ingestion. Glass FRSCC showed best execution in fresh state. The current examination infers that as far as generally exhibitions, ideal dose and cost Basalt Fiber is the most ideal alternative in improving by and large nature of self compacting concrete.

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 Keywords

FIBER MATERIALS, CARBAN FIBER, BASALT FIBER, GLASS FIBER.

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