Volume 12 | Issue 5 |

 Abstract

The article talks about the several strategies for ensuring the cloud computing system is reliable. It goes over the Markov Chain, Weibull processes, Risk Priority Number, Reliability Block Diagram, and Fault Tree Analysis. The client experience is enhanced by the dependability of the cloud system's hardware and software components. The probability of the state transition and the Markov chain are used to represent the reliability prediction. The state-of-the-art review of the fuzzy system in the event of linguistic imprecision is provided by this study. The stability of the cloud system may benefit from the hybrid fuzzy-probabilistic system.

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Cloud Computing, Mathematical Modeling, Reliability

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Dengue fever, a mosquito-borne viral infection, commonly presents with fever, headache, myalgia, and thrombocytopenia. Hepatic involvement, characterized by elevated liver enzymes, is a recognized complication of dengue infection. However, coinfection with hepatitis in Dengue Hemorrhagic Fever (DHF) is uncommon. Here, we report a case of a 25-year-old male presenting with DHF complicated by acute hepatitis coinfection. The patient exhibited fever, abdominal pain, jaundice, thrombocytopenia, and markedly elevated liver enzymes. Laboratory investigations confirmed Dengue NS1 antigen positivity and concurrent acute hepatitis. This case underscores the importance of recognizing and managing coinfections in patients with dengue fever to prevent complications and improve outcomes

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Hepatitis and Haemorrhagic fever -Co infection

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Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive hematological malignancy with limited treatment options. The development of tagraxofusp, a CD123-directed recombinant fusion protein, has revolutionized the management of BPDCN. This manuscript reviews the current understanding of BPDCN pathophysiology, clinical presentation, and diagnostic challenges. We delve into the mechanisms of action of tagraxofusp, explore its clinical efficacy and safety profile, and discuss its role as a potential frontline and salvage therapy. Additionally, we highlight ongoing research and future directions to optimize the use of tagraxofusp in BPDCN treatment.

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Blastic plasmacytoid dendritic cell neoplasm, hematological maliganancy, recombinant fusion protein,recombinant fusion protein

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Introduction: Employee engagement plays a vital role in the success of any organization. Within this context, human resources managers are crucial in designing strategies to promote employee engagement. Methodology: This study employs a qualitative phenomenological research design to explore the lived experiences of human resources managers in promoting employee engagement within their organizations. The study involves conducting in-depth interviews with ten human resources managers across various industries. The central question guiding this research is: "What strategies do Human Resource Managers use to promote a culture of engagement within their organizations?" Data was gathered through twenty-five semi-structured interviews and analyzed using an inductive approach to develop themes. Results: This study identified three emerging themes: Performance Management, Talent Management, and Team Management. The findings reveal that Performance Management involves using surveillance methods to provide feedback during and after appraisals. Talent Management includes implementing motivational factors to boost team morale, recognizing and appreciating employees, and providing professional education for employee growth. Team Management involves fostering teamwork, where individuals share ideas and skills to achieve shared objectives, thus promoting communication and cooperation within the workplace. Discussion: The three themes are crucial for human resource managers in promoting employee engagement because they collectively contribute to fostering a positive work environment, enhancing employee satisfaction, and ultimately improving organizational performance. Recommendations: This research paper contributes to the existing literature on employee engagement and therefore recommends that future researchers conduct related studies of employee engagement exploring other variables such as productivity, employee well-being, and satisfaction. The human resource managers can also use this paper to effectively promote employee engagement and foster a culture of open communication and collaboration to manage talent and performance within their team.

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Collaborating, Communication, Employee Engagement, Monitoring, Feedback, Recognition, Organization, Performance

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"Evaluating Marketed Metformin Hydrochloride (500mg) Tablets: A Comparative In-Vitro Approach", aims to assess the quality and performance of various commercially available Metformin hydrochloride tablets through in-vitro testing methods. By comparing different brands or formulations, the project seeks to identify potential differences in drug release profiles, dissolution rates, and other critical parameters that may impact therapeutic effectiveness and patient outcomes. This research contributes valuable insights to pharmaceutical quality control and assists healthcare professionals in making informed decisions regarding medication selection and management for patients with diabetes or other conditions treated with Metformin.

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Metformin hydrochloride, In-vitro Study

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Artificial Intelligence (AI) is becoming more common in our lives, including in College/Universities. A study asked 38 people about how AI affects learning and thinking. It found that AI is most useful for tasks like studying for exams, problem-solving, and doing assignments. People see both good and bad sides to AI. Some like how it personalizes learning and helps to solve problems, but others worry it might make people lazy or less creative. Still, many think AI can help students learn independently by giving quick help, organizing thoughts, and improving problem-solving skills. People see AI as a tool to help, it cannot replace a human intelligence. It might even help with language skills and encourage creative thinking. Some worries include losing jobs, less creativity, and not having real-life experiences. But most don't think AI makes us worse at decision-making or less active. Overall, people believe AI helps us think better, find new solutions, and teach better. People have different opinions about trusting AI answers compared to answers from friends or teachers. This study shows that AI in education has both good and bad sides, and we need to think carefully about how we use it.

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THE IMPACT OF AI ON COLLEGE STUDENT'S INTELLECTUAL DEVELOPMENT

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While the retail grocery industry in India is one of the fastest-growing, retail businesses in the country compete with one another for the limited consumer base. The E grocery retailers ought to be able to draw in customers and use marketing to interact with them. The retailers of E-grocery should be able to draw in customers and engage with them through marketing since it focuses on finding multiple organizational variables that impact the notion of lean marketing readiness: Lean awareness, Lean principles, Knowledge on lead deadly wastes .Lean tools and techniques, Perception on lean, implementation benefits, Perception on lean implementation. The aim of the study was to determine the factors contributing to the lean awareness and to understand perceptions of retailers on lean thinking which can help to progress the further research. The study helps retailers of e grocery marts to understand and develop ways to adopt the Lean marketing strategies in turn can produce value for the customers through the optimization of the resources and create a steady workflow based on real customers' demands

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retail businesses, Lean awareness, Perception on lean, lean implementation, variables, factors

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A potentially effective method of bypassing the barrier between the blood and the brain and delivering medicinal substances straight to the brain is the nose-to-brain medication delivery system. The state-of-the-art in nose-to-brain medication delivery systems is thoroughly reviewed in this paper, with an emphasis on recent developments, difficulties, and potential future directions. The nasal route has several benefits for delivering drugs to the brain, such as a rich blood supply, a wide surface area, and the ability to bypass first-pass metabolism. To improve medication transport through the nasal passages to the brain, a number of approaches have been investigated, such as the use of mucoadhesive formulations, nasal irrigation methods, and nanocarriers. The efficiency & targeting abilities of nose to brain delivery systems are significantly enhanced by nanotechnology. medications may be delivered continuously and with regulated release thanks to nanocarriers including liposomes, nanoparticles, and nano emulsions, which also increase the medications' bioavailability and therapeutic effectiveness. By limiting systemic adverse effects, surface modification approaches enable tailored delivery to certain brain areas. By maintaining longer contact with the nasal mucosa and facilitating absorption into the systemic circulation or direct transfer to the brain, mucoadhesive formulations improve medication retention in the nasal cavity. Mucoadhesive systems based on polymers, such hydrogels and microspheres, have shown potential in enhancing medication absorption and retention. Nasal irrigation methods provide a non-invasive and patient-friendly way to administer medication. These methods include nasal sprays and nebulizers. By administering medications in an aerosolized form, these devices enable quick absorption through the nasal epithelium and direct delivery of the medication to the brain through the olfactory and trigeminal pathways. Even with great advancements, there are still a number of issues with nose-to-brain medication administration that need to be resolved, such as the removal of nasal mucociliary cells, the breakdown of enzymes, and architectural obstructions in the nasal canal. In addition, a thorough assessment of the long-term impacts on the nasal mucosa and the safety profile of nanocarriers is required. Neap-to-brain medication delivery devices are particularly promising for treating Parkinson's disease, Alzheimer's disease, and brain tumors, among other neurological conditions. To fully realize the promise of this novel technique in clinical practice, more study is needed to overcome current obstacles and optimize delivery strategies.

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Nose-to-brain drug delivery, Blood-brain barrier, Nanotechnology, Nanocarriers, Nasal irrigation techniques, Controlled release, Sustained delivery, Surface modification, olfactory and trigeminal nerve

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Within cloud environments, Searchable Encryption (SE) serves as a vital tool for protecting data while maintaining its accessibility. The Cipher text-Policy Attribute-Based Keyword Search (CP-ABKS) relies on Ciphertext-Policy Attribute-Based Encryption (CP-ABE) to allow for keyword retrieval and precise access control. However, existing CP-ABKS setups face challenges due to their dependence on a single attribute authority for user certificate validation and secret key distribution. This reliance leads to performance bottlenecks in distributed cloud setups. To address this issue, our research introduces a secure Multi-authority CP-ABKS (MABKS) system. This system aims to overcome these limitations and reduce computational and storage overhead on resource-constrained devices within cloud infrastructures. Additionally, enhancements have been made to the MABKS system to enable the detection of fraudulent attribute authorities and facilitate attribute updates

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Cipher text-Policy Attribute-Based Encryption, MABKS, , Multi-authority CP-ABKS

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Creative Commons Attribution 4.0 and The Open Definition

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