Volume 12 | Issue 8 |

 Abstract

This case report describes a rare presentation of a nodular lesion on the index finger of an adult patient, histologically confirmed as tuberous xanthoma. The report highlights clinical features, histopathological findings, including Giemsa and Hematoxylin & Eosin (H&E) staining, and discusses the diagnostic process, management strategies, and the patient's clinical course.

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A Rare Presentation of Tuberous Xanthoma in an Adult Patient: A Case Report and Literature Review

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Bank workers are the employees who are subjected to risk factors like long working hours, static posture, poor office ergonomics and repetitive nature of work leading to pain and discomfort. Approximately 40.4% of bankers reported of mechanical low back pain in various studies conducted. Thus, to study the effect of kitchen table exercise program on pain, strength and range of motion Bank workers with chronic mechanical low back pain is essential for the well-being and to reduce discomfort in them. The subjects were selected according to the inclusion criteria and divided into two groups. Pre-test and post-test assessment was done in which Visual Analogue Scale was used for pain, goniometer for range of motion and stabilizer pressure biofeedback for strength were used. The study was conducted on 62 subjects in two groups where Group A was given Kitchen table exercise program and Group B was given conventional exercises for 12 weeks each. Both groups showed significant improvement in pain, range of motion and strength but group A showed more improvement than group B. This study concludes that there was a significant reduction in pain and significant increase in range of motion and strength in bank workers with chronic mechanical low back pain.

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Kitchen table exercise, pain, range of motion, strength, bank workers

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Fixed point theorems and contraction mappings are essential components of mathematical analysis with significant theoretical and practical applications. This study delves into the fundamental concepts of fixed points and contraction mappings, exploring their mathematical properties, proof techniques, and diverse applications. We begin with a comprehensive review of classical fixed point theorems, including the Banach, Brouwer, and Schauder theorems, highlighting their unique properties and implications. The theoretical analysis is complemented by rigorous proofs and the formulation of new theorems that extend existing results to broader contexts. Our methodology includes the development of iterative algorithms based on contraction mappings, which are implemented and tested through computational experiments. We perform convergence and error analysis to evaluate the efficiency and robustness of these algorithms. Practical applications are explored in various fields such as differential equations, optimization, economics, and computer science, demonstrating the versatility and utility of fixed point theorems. The data analysis phase involves both theoretical exploration and computational validation, using statistical and graphical methods to interpret the results. Case studies on solving differential equations and optimization problems illustrate the practical impact of fixed point methods. The findings are documented and presented through detailed visualizations and comparative analyses, providing a clear understanding of the efficiency and applicability of the developed algorithms. This study not only advances the theoretical framework of fixed point theorems and contraction mappings but also provides powerful tools for solving real-world problems, emphasizing the importance of these concepts in both mathematical research and practical applications.

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Fixed Point Theorems, Contraction Mappings, Banach Fixed Point Theorem, Brouwer Fixed Point Theorem, Schauder Fixed Point Theorem, Nonlinear Analysis, Differential Equations, Game Theory, Stability and Sensitivity

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Work and family conflict occurs when there are incompatible demands between the work and family roles of an individual that makes participation in both roles more difficult. The study is about Work-Family Conflict among Nurses in Coimbatore Hospitals. The main objective of the study is to identify the influence of personal profile of nurses on various variables of Work-Family Conflict and to know whether marital status influences the factors of the work family conflict. For this purpose, a sample of 150 is collected from the respondents based on survey method. The statistical tools like Anova and t-test were used for analysing the data. This Study Suggest that generating awareness towards Work Family Conflict may help them to handle it. They can inculcate the art of time management by mentor through some programs. The management can arrange for family tours, picnics or for a get together at periodic intervals. This would help to increase the rapport with the nurses. The hospital management can also provide proper training like different methods to toggle the patients' tension, stress free activities, yoga, etc. The study reveals that Work-Family conflict of nurses is influenced more by work and family role variables. Mostly the Family Social support influences the work family conflict than Work Place support. While taking care of the health of others, it is important that nurses should learn and use the methods and techniques to take care of their own health also.

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Rapport, Time Management, Work Family Conflict

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Abstract: The burgeoning field of personalized pharmacology promises to revolutionize medical treatment by tailoring therapeutic strategies to individual genetic profiles. Integrative bioinformatics, a discipline that combines computational tools and biological data, is at the forefront of this transformation. By leveraging vast datasets from genomics, proteomics, and metabolomics, bioinformatics approaches enable the identification of biomarkers and the prediction of drug responses, thereby facilitating the development of personalized medicine. This paper explores the future perspectives and applications of integrative bioinformatics in personalized pharmacology. It highlights the key technologies and methodologies, such as machine learning, data mining, and systems biology, that are driving advancements in this field. The integration of multi-omics data is emphasized as a critical factor in understanding the complex interactions between genes, proteins, and metabolites that influence drug efficacy and safety. Moreover, the paper discusses the role of electronic health records (EHRs) and real-world data in enhancing the accuracy of bioinformatics models, thus ensuring more precise and individualized treatment plans. Recent advancements in artificial intelligence (AI) and machine learning are also examined, demonstrating how these technologies are being used to predict adverse drug reactions and optimize drug dosages. The application of network pharmacology and pharmacogenomics is reviewed, providing insights into how these approaches contribute to the identification of novel drug targets and the repurposing of existing drugs for personalized therapy. Despite the promising advancements, several challenges remain, including data integration, standardization, and the need for robust validation frameworks. Ethical considerations, such as patient privacy and data security, are also addressed, underscoring the importance of developing transparent and secure bioinformatics systems. In conclusion, integrative bioinformatics is poised to significantly impact personalized pharmacology, offering new avenues for research and clinical practice. By overcoming current challenges and leveraging technological advancements, the future of personalized medicine holds great potential for improving patient outcomes and optimizing therapeutic interventions. This paper provides a comprehensive overview of the state-of-the-art approaches and future directions in integrative bioinformatics for personalized pharmacology, aiming to inform and inspire further research and development in this dynamic field.

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Bioinformatics, Pharmacology, Clinical Practice, Personalized Therapy

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The present research paper is an attempt to make the spatial analysis of availability of household amenities in Patna Municipal Corporation Area. The study is based on secondary source of data, collected from Houselisting and Housing Census Data, 2011. The study reveals that the development of household amenities is higher in central and southern parts of Patna Municipal Corporation area while the northern and eastern part of the city is least developed in this regard

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Household Amenities, Patna, Municipal Corporation Area, ward

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Nanotechnology is relatively a new branch of science that has found a wide range of applications which ranges from energy production to biomedical applications. In present study, ZnO nanoparticles are synthesized using fresh leaf extract Morinda citrifolia by Co-precipitation method. The synthesized nanoparticles are characterized by X-Ray diffraction analysis (XRD), Fourier Transform Infrared spectral analysis (FTIR), UV-Visible spectral analysis (UV-Vis), Scanning Electron Microscopy (SEM), Energy Dispersive X-Ray analysis (EDX) and Antimicrobial activity. From XRD, the particle size of ZnO Nps is determined and is about 15.77 nm. The presence of biomolecules and functional groups are investigated by FTIR analysis. The band gap energy of ZnO Nps is estimated using UV-Vis Spectral analysis and it is approximately 3.31eV. The surface morphology and elemental composition of ZnO Nps is observed under SEM and EDX. The inhibition zone of ZnO Nps is determined by antibacterial activity and results increasing zone of inhibition for various concentration of sample. The ZnO Nps shows moderate activity against HT-29 cell lines.

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Nanotechnology; Green synthesis; Zinc oxide nanoparticle; Morinda citrifolia; antibacterial activity; anticancer activity

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Elections were fundamental to democratic governance. Issues such as voter turnout, engagement, and generational preferences impact electoral outcomes. The significance of millennial participation had drawn attention, both globally and in the Philippines. The study examined the voting behavior and preferences of millennials in Tarlac City, revealing key demographic insights and their impact on electoral choices. The study used quantitative correlational research to explore connections between variables like demographics, voting behavior, and preferences among millennials in Tarlac City. Data collection involved questionnaires, interviews, and documentary analysis. The respondents were randomly and conveniently selected to get a diverse sample, and the data were analyzed using statistical tests and software to find patterns in millennials' preferences and behaviors when voting. The research highlighted personality traits, particularly thoughtfulness, as crucial in candidate selection. Security platforms were the primary concern for voters. The political or family background of candidates significantly influenced millennial voting behavior. Social and peer pressure affected the respondents. Governance skills and leadership style were highly valued in candidates. And traditional campaign methods, like rallies and caucuses, were preferred. The study found significant correlations between various demographic profiles and voting behavior. Age, gender, education, marital status, occupation, and religion all play critical roles in shaping political preferences. Addressing election challenges, such as vote buying and procedural issues, was essential for ensuring a fair and inclusive electoral process. It is recommended to target millennials with voter education campaigns, modernize electoral processes with technology, and provide additional precincts. They may establish monitoring systems to assess interventions and campaign managers to commit to ethical practices and use innovative tactics to engage millennials were also recommended.

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Voter engagement, voting behavior and preferences, election, Millennials voting patterns

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ADJUSTMENT AS ACHIEVEMENT Adjustment as achievement means how efficiency an individual can perform his duties in different circumstances. Coob (1972) examined the relationship between the frequency of a specific task oriented behaviour and academic achievement in fourth grade children. The results obtained are that over task oriented and social behaviour in the class room may be an important academic progress.

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Adjustment Problem , Secondary Student

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