Volume 12 | Issue 8 |

 Abstract

This study aimed to develop and optimize Oro-Dispersible Tablets (ODTs) of Bilastine, a second-generation antihistamine, using Cotton Candy (CC) and Direct Compression (DC) methods. Bilastine ODTs were formulated with varying concentrations of superdisintegrants, sweeteners and lubricants. The CC method utilized a novel approach of incorporating Bilastine into partially recrystallised granules prepared from cotton candy fibers, while the DC method employed a conventional tableting process. Formulations were evaluated for disintegration time, wetting time, hardness, friability, and in vitro drug release. Optimization was achieved through a Design of Experiments (DoE) by using Central Composite Design (CCD) approach, resulting in ODTs with disintegration times of < 30 seconds and drug release > 90% in 10 minutes. The generated batches were prepared and evaluated. The BLS6 was given as the best batch by the design expert software using central composite design (CCD). In-vitro drug release of the optimized formulation (BLS6) was obtained 98.83 % in 10 min and disintegration time within 13.00 seconds. Characterization studies revealed that CC-ODTs exhibited faster disintegration and superior drug release profiles. These findings demonstrate the potential of Cotton Candy technology in developing rapid-disintegrating, high-performance ODTs of Bilastine, offering improved patient compliance and therapeutic outcomes.

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 Keywords

Oro-Dispersible Tablets, Bilastine, Cotton Candy, Direct Compression, Superdisintegrants, Design of Experiments.

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

ABSTRACT Present paper analyses the Urban local government is the responsibility of the department of local self- government in the state. At the state level a number of department deals with subjects which are the direct concern of the urban government. In addition to the department of local self-government the functional departments in the secretariat administer the various components of urban development. Thus water supply, drainage and sewerage, road construction, land acquisition and development, housing and slum clearance, etc. are being dealt with by respective functional departments.

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Keywords: Urban Development Agency, Bureaucratic interference, political interference, financial autonomy.

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Bharat me audyogik viaksh ka mahatva avm samsya

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Creative Commons Attribution 4.0 and The Open Definition

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Bharat me audyogik viaksh ka mahatva avm samsya

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Creative Commons Attribution 4.0 and The Open Definition

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Art and culture both are important for integrating in education because these create a cooperative nature among the students. Not only bookish knowledge is helpful for the students but also through this art and culture students can conduct the education with the real life experience. Through integrating art in the education system students can build their critical thinking skills. They can relate their education with the practical life situation. And culture also helps the students for improving their social interaction, how to behave with their family members how to behave with their parents, how to behave with their peer groups and siblings and also how to behave with the social people. Education with art and culture helps students explore their emotions, encouraging empathy and emotional intelligence. By expressing themselves through various art forms, students learn to understand and respect diverse perspectives, fostering tolerance and harmony in society.

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Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Creativity, Real life experience, Imagination, Problem Solving Skill, Art and Culture, Society, Social Behavior, Values and Norms, innovation, holistic development.

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Creative Commons Attribution 4.0 and The Open Definition

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The hazard analysis and management are vital in textile industry to avoid losing customers and wasting resources caused by the failures in production systems. Risk analysis is also very significant to decrease possible hazards and to avoid possible damage in production systems. In this study, an approach based on Failure Mode and Effects Analysis (FMEA) and Fault Tree Analysis (FTA) is proposed to analyze the ring spinning yarn production process in a textile industry. First, the possible hazards in the production line, yarn production system, in an integrated company operating in the textile sector are analyzed by FTA method. Then, FMEA is applied to ring spinning yarn production process in a textile industry to rank all possible risks corresponding to hazards in descending order with respect to both occupational health and safety. It is very important to remove all possible hazards in textile industry to decrease the number of risks related to occupational health and safety. Therefore, in total of 57 hazard root causes are determined in the yarn production department. Subsequently, the faults related to the hazard root causes are examined by FTA and then risk corresponding to these hazards are prioritized by FMEA. The results obtained from the proposed FTA-FMEA approach show that decision makers and engineers can easily decrease the number of hazards and risks with respect to both occupational health and safety in practice.

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Safety, Failure Mode and Effects Analysis, Hazard and Risk Assessment.

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The study focusses on the preclinical development of anxiolytic herbal drug Gotu Kola, which is used as an anxiolytic. The drug's anxiolytic activity was tested on wrister albino rats, following module 4 of the CTD. Animal experiments were conducted, including open field tests, elevated plus maze tests, and light and dark apparatus tests. Dopamine and acetylcholine esterase estimation were performed. Results showed that a single dose of Gotu Kola and a combined dose of caffeine and Gotu Kola alleviate anxiety. Similar effects were observed in the elevated plus maze test and open field test. Mandhukhpqrni and it's combination with caffeine effects in open field test. Combined administration increases the acetylcholine esterase and dopamine level in brain. The study adheres to regulatory authorities' rules and regulations.

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 Keywords

Gotu kola , Preclinical study, CTD

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Creative Commons Attribution 4.0 and The Open Definition

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Abstract: This research looks at how well blue-chip mutual funds perform in the banking industry. It focuses on risk-return trade-offs and performance evaluation utilizing metrics including Jensen's Alpha, Treynor Ratio, and Sharpe Ratio. Three years' worth of data are included in the investigation, which includes major mutual funds like SBI, Canara, Kotak, and others. The results show that annual returns fluctuate, showing positive returns during times of good market circumstances and negative returns during difficult times. Since volatility differs throughout funds, it is crucial to take risk into account while making investment decisions. While risk-adjusted performance indicators provide information about the effectiveness of fund management strategies, beta values show market sensitivity. Investors are given recommendations that prioritize risk-adjusted returns, diversity, and well-informed decision-making.

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Blue chip mutual funds, Banking sector, Risk-return trade-off, Performance analysis

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Creative Commons Attribution 4.0 and The Open Definition

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Amidst a global economic downturn, the Indian economy stands out as a more promising prospect. The Indian government has committed to improving the ease of doing business, promoting market integrity, and expanding corporate governance, which has boosted investor and stakeholder confidence. Achieving these objectives requires good governance and strong frameworks. Corporate governance is gaining momentum in India due to past failures, unethical practices, and insufficient disclosures. In recent years, the frequency, intensity, and magnitude of corporate governance failures have increased. India has seen examples of entities with good and bad corporate governance, including Kingfisher Airlines, Jet Airways, Punjab National Bank, DHFL, PMC Bank, Infrastructure Leasing & Financial Services (IL&FS), Rotomac Bank Fraud, and Videocon-ICICI Bank. The Companies Act 2013 has given Independent Directors more power and responsibility, making them responsible for any shortcomings in corporate governance. Independent Directors play an active role in various committees to ensure good governance and protect the interests of all stakeholders. This article, based on secondary data and the Company Auditor's Report Order (CARO), highlights the key areas where an Independent Director can play a proactive role in sensing early warning signs, detecting them in advance, taking preventive measures, and mitigating risks that may arise. In recent corporate frauds, analysing the roles of Independent Directors has revealed that they either did not play their role effectively, were not aware of the issues, or could not read the early warning signs properly. Author through this article has emphasised on the key areas which are to be watched carefully and Independent Directors can sense reflags from there. If they are proactive and keep their eyes open and regularly track these areas they can avoid certain frauds. This article will help directors to be more aware abut the key areas and how to use these indicators to avoid fraud in their organization.

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 Keywords

Independent Directors, Red Flags, Watch Dog Fraud, Early Warning Signs

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Nowadays, almost all organizations focus on adopting cloud computing approaches for Internet of Things (IoT) applications. Integrating IoT devices with cloud computing technology is considered an effective method for storing and managing the enormous amount of data generated by various devices. However, ensuring the security of big data within these organizations presents a challenge in the IoT-cloud architecture. To address security concerns, we propose a cloud-enabled IoT environment supported by multifactor authentication and lightweight cryptographic encryption schemes to protect the big data system. The proposed hybrid cloud environment aims to secure organizations' data in a highly secure manner. This hybrid cloud environment combines private and public clouds. In this setup, we encrypt the data using AES, and the cloud provides additional security. Users who request access to a file must obtain a decryption key from a Trusted Authority (TA). Only those who receive keys from the TA can decrypt the file and access it in its original form. The performance of the proposed architecture is evaluated using metrics such as computational time, security strength, encryption time, and decryption time.

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 Keywords

Cloud Computing, Internet of Things (IoT), Big Data Security, Multifactor Authentication, Lightweight Cryptography, AES Encryption, Hybrid Cloud Environment, Private Cloud, Public Cloud, Trusted Authority (TA), Data Encryption, Data Decryption, Computational Time, Security Strength, Encryption Time, Decryption Time.

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Creative Commons Attribution 4.0 and The Open Definition

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Abstract Education is an important aspect for everyone's development. It helps in all round development of an individual. It opens various opportunities in life. Similarly mathematics education is important for everyone as it is more closely to our daily life as compared to other subjects. Mathematics is so valuable, important, psychologically based and so closely connected with our day to day life, justified to be included in school curriculum. A sighted person acquire around 80-85% of information through vision. In case of visual disabilities (divyangjan) it is not so, they face various kinds of difficulties in acquiring information from their environment. They use their remaining senses to get information from their surroundings. They use multi-sensory approach to learn their subjects. Their teachers should make them to learn converting visual ideas to non-visual information through multi-sensory approach. Mathematics is a subject which has its own language, symbols, full of pictorial representations, abstract nature, and graphs/ diagrams etc.. The nature of mathematics itself is a barrier for students with visual disabilities. To make the student with visual disabilities to understand the concept, Nemeth Braille Code plays major role to access Mathematics. Adequate and effective use of Nemeth Braille Code can overcome the hurdles in mathematics education among students with visual disabilities. They can learn almost each and every mathematical concepts by using this Code. This paper gives an overview of Nemeth Braille Code in getting mathematics education among students with visual disabilities.

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 Keywords

Key words: Mathematics, Student with Visual disabilities, Nemeth Braille Code, Divyangjan

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Creative Commons Attribution 4.0 and The Open Definition